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HMGB2

GENERAL INFORMATION

Gene name

 HMGB2

Gene description

 High mobility group box 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA003506 , HPA053314 , CAB037206
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), melanoma (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Melanoma p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA003506
HPA053314
CAB037206

GENE INFORMATION

Gene name

 HMGB2 (HGNC Symbol)

Synonyms

 HMG2

Description

 High mobility group box 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q34.1

Chromosome location (bp)

 173331695 - 173335125

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164104 (version 83.38)

Entrez gene

 3148

UniProt

 P26583 (UniProt - Evidence at protein level)

neXtProt

 NX_P26583

Antibodypedia

 HMGB2 antibodies

PROTEIN BROWSER
HMGB2-001
HMGB2-003
HMGB2-004
HMGB2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMGB2-001
ENSP00000296503
ENST00000296503
P26583 [Direct mapping]
High mobility group protein B2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000400 [four-way junction DNA binding]
GO:0000790 [nuclear chromatin]
GO:0000793 [condensed chromosome]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006265 [DNA topological change]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007283 [spermatogenesis]
GO:0007289 [spermatid nucleus differentiation]
GO:0008134 [transcription factor binding]
GO:0008144 [drug binding]
GO:0008301 [DNA binding, bending]
GO:0008584 [male gonad development]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0019904 [protein domain specific binding]
GO:0032075 [positive regulation of nuclease activity]
GO:0032392 [DNA geometric change]
GO:0032496 [response to lipopolysaccharide]
GO:0032728 [positive regulation of interferon-beta production]
GO:0033151 [V(D)J recombination]
GO:0042056 [chemoattractant activity]
GO:0042493 [response to drug]
GO:0043234 [protein complex]
GO:0043388 [positive regulation of DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044378 [non-sequence-specific DNA binding, bending]
GO:0044822 [poly(A) RNA binding]
GO:0045089 [positive regulation of innate immune response]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045654 [positive regulation of megakaryocyte differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048545 [response to steroid hormone]
GO:0050767 [regulation of neurogenesis]
GO:0050786 [RAGE receptor binding]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0060326 [cell chemotaxis]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0072091 [regulation of stem cell proliferation]
GO:0097100 [supercoiled DNA binding]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 209 aa
24 kDa 		No 0
HMGB2-003
ENSP00000393448
ENST00000446922
P26583 [Direct mapping]
High mobility group protein B2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000400 [four-way junction DNA binding]
GO:0000790 [nuclear chromatin]
GO:0000793 [condensed chromosome]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006265 [DNA topological change]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008134 [transcription factor binding]
GO:0008144 [drug binding]
GO:0008301 [DNA binding, bending]
GO:0012501 [programmed cell death]
GO:0032075 [positive regulation of nuclease activity]
GO:0032392 [DNA geometric change]
GO:0032496 [response to lipopolysaccharide]
GO:0033151 [V(D)J recombination]
GO:0042056 [chemoattractant activity]
GO:0042493 [response to drug]
GO:0043234 [protein complex]
GO:0043388 [positive regulation of DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044378 [non-sequence-specific DNA binding, bending]
GO:0044822 [poly(A) RNA binding]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045654 [positive regulation of megakaryocyte differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050767 [regulation of neurogenesis]
GO:0050786 [RAGE receptor binding]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0060326 [cell chemotaxis]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0072091 [regulation of stem cell proliferation]
GO:0097100 [supercoiled DNA binding]
Show all
 209 aa
24 kDa 		No 0
HMGB2-004
ENSP00000404912
ENST00000438704
P26583 [Direct mapping]
High mobility group protein B2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000400 [four-way junction DNA binding]
GO:0000790 [nuclear chromatin]
GO:0000793 [condensed chromosome]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006265 [DNA topological change]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008134 [transcription factor binding]
GO:0008144 [drug binding]
GO:0008301 [DNA binding, bending]
GO:0012501 [programmed cell death]
GO:0032075 [positive regulation of nuclease activity]
GO:0032392 [DNA geometric change]
GO:0032496 [response to lipopolysaccharide]
GO:0033151 [V(D)J recombination]
GO:0042056 [chemoattractant activity]
GO:0042493 [response to drug]
GO:0043234 [protein complex]
GO:0043388 [positive regulation of DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044378 [non-sequence-specific DNA binding, bending]
GO:0044822 [poly(A) RNA binding]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045654 [positive regulation of megakaryocyte differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050767 [regulation of neurogenesis]
GO:0050786 [RAGE receptor binding]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0060326 [cell chemotaxis]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0072091 [regulation of stem cell proliferation]
GO:0097100 [supercoiled DNA binding]
Show all
 209 aa
24 kDa 		No 0
HMGB2-005
ENSP00000423001
ENST00000506267
D6R9A6 [Direct mapping]
High mobility group protein B2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
Show all
 134 aa
15.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.