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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MAD2L1
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MAD2L1

Gene description

MAD2 mitotic arrest deficient-like 1 (yeast)

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA003348
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA003348

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Moderate cytoplasmic immunoreactivity was observed in several cases of colorectal, thyroid, gastric and liver cancers. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

MAD2L1 (HGNC Symbol)

Synonyms

HSMAD2, MAD2

Description

MAD2 mitotic arrest deficient-like 1 (yeast) (HGNC Symbol)

Entrez gene summary

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q27

Chromosome location (bp)

120055608 - 120067074

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164109 (version 83.38)

Entrez gene

4085

UniProt

Q13257 (UniProt - Evidence at protein level)

neXtProt

NX_Q13257

Antibodypedia

MAD2L1 antibodies

PROTEIN BROWSER

MAD2L1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAD2L1-001
ENSP00000296509
ENST00000296509
Q13257 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD2A
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005829 [cytosol]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0060564 [negative regulation of APC-Cdc20 complex activity]
GO:0072686 [mitotic spindle]
GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint]
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205 aa
23.5 kDa
No 0

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