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GUCY1A3

GENERAL INFORMATION

Gene name

 GUCY1A3

Gene description

 Guanylate cyclase 1, soluble, alpha 3

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Karpas-707, MOLT-4, RPTEC TERT1, RT4, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression, most prominent in glandular cells of gastrointestinal tract, prostate and cerebral cortex.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA056004 , CAB010887
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable), testis cancer (unfavourable) and renal cancer (unfavourable).
Lung cancer p<0.001
Testis cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA056004
CAB010887

GENE INFORMATION

Gene name

 GUCY1A3 (HGNC Symbol)

Synonyms

 GC-SA3, GUC1A3

Description

 Guanylate cyclase 1, soluble, alpha 3 (HGNC Symbol)

Entrez gene summary

 Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 4

Cytoband

 q32.1

Chromosome location (bp)

 155666711 - 155732349

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164116 (version 83.38)

Entrez gene

 2982

UniProt

 Q02108 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02108

Antibodypedia

 GUCY1A3 antibodies

PROTEIN BROWSER
GUCY1A3-001
GUCY1A3-002
GUCY1A3-005
GUCY1A3-006
GUCY1A3-009
GUCY1A3-010
GUCY1A3-013
GUCY1A3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GUCY1A3-001
ENSP00000421493
ENST00000511108
Q02108 [Direct mapping]
Guanylate cyclase soluble subunit alpha-3
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
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 690 aa
77.5 kDa 		No 0
GUCY1A3-002
ENSP00000424361
ENST00000506455
Q02108 [Direct mapping]
Guanylate cyclase soluble subunit alpha-3
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
Show all
 690 aa
77.5 kDa 		No 0
GUCY1A3-005
ENSP00000426968
ENST00000511507
Q02108 [Direct mapping]
Guanylate cyclase soluble subunit alpha-3
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
Show all
 624 aa
70.2 kDa 		No 0
GUCY1A3-006
ENSP00000412201
ENST00000455639
Q02108 [Direct mapping]
Guanylate cyclase soluble subunit alpha-3
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
Show all
 690 aa
77.5 kDa 		No 0
GUCY1A3-009
ENSP00000377418
ENST00000393832
J3KPQ8 [Direct mapping]
Guanylate cyclase soluble subunit alpha-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0004383 [guanylate cyclase activity]
GO:0005622 [intracellular]
GO:0006182 [cGMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 432 aa
48.5 kDa 		No 0
GUCY1A3-010
ENSP00000296518
ENST00000296518
Q02108 [Direct mapping]
Guanylate cyclase soluble subunit alpha-3
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0008217 [regulation of blood pressure]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0009635 [response to herbicide]
GO:0014070 [response to organic cyclic compound]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0030828 [positive regulation of cGMP biosynthetic process]
GO:0035556 [intracellular signal transduction]
GO:0043167 [ion binding]
GO:0043234 [protein complex]
GO:0046982 [protein heterodimerization activity]
GO:0052565 [response to defense-related host nitric oxide production]
GO:0060087 [relaxation of vascular smooth muscle]
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 690 aa
77.5 kDa 		No 0
GUCY1A3-013
ENSP00000426040
ENST00000513574
Q02108 [Direct mapping]
Guanylate cyclase soluble subunit alpha-3
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0020037 [heme binding]
GO:0035556 [intracellular signal transduction]
Show all
 690 aa
77.5 kDa 		No 0
GUCY1A3-201
ENSP00000479710
ENST00000621234
Q6PJR4 [Direct mapping]
GUCY1A3 protein; Guanylate cyclase 1, soluble, alpha 3, isoform CRA_c; Guanylate cyclase soluble subunit alpha-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 143 aa
16.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.