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ARFIP1

GENERAL INFORMATION

Gene name

 ARFIP1

Gene description

 ADP-ribosylation factor interacting protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA037375 , HPA063759 , CAB005080
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037375
HPA063759
CAB005080

GENE INFORMATION

Gene name

 ARFIP1 (HGNC Symbol)

Synonyms

 HSU52521

Description

 ADP-ribosylation factor interacting protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q31.3

Chromosome location (bp)

 152687727 - 152918463

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164144 (version 83.38)

Entrez gene

 27236

UniProt

 P53367 (UniProt - Evidence at protein level)

neXtProt

 NX_P53367

Antibodypedia

 ARFIP1 antibodies

PROTEIN BROWSER
ARFIP1-001
ARFIP1-002
ARFIP1-003
ARFIP1-004
ARFIP1-201
ARFIP1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARFIP1-001
ENSP00000395083
ENST00000451320
P53367 [Direct mapping]
Arfaptin-1
B4E273 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor interacting protein 1 (Arfaptin 1), isoform CRA_b; ARFIP1 protein; cDNA FLJ53696, highly similar to Arfaptin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0019904 [protein domain specific binding]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0050708 [regulation of protein secretion]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
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 373 aa
41.7 kDa 		No 0
ARFIP1-002
ENSP00000396653
ENST00000429148
P53367 [Direct mapping]
Arfaptin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0019904 [protein domain specific binding]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0050708 [regulation of protein secretion]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
Show all
 193 aa
22.1 kDa 		No 0
ARFIP1-003
ENSP00000384189
ENST00000405727
P53367 [Direct mapping]
Arfaptin-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0019904 [protein domain specific binding]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0050708 [regulation of protein secretion]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
Show all
 341 aa
38.6 kDa 		No 0
ARFIP1-004
ENSP00000348360
ENST00000356064
P53367 [Direct mapping]
Arfaptin-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0019904 [protein domain specific binding]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0050708 [regulation of protein secretion]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
Show all
 341 aa
38.6 kDa 		No 0
ARFIP1-201
ENSP00000296557
ENST00000353617
P53367 [Direct mapping]
Arfaptin-1
B4E273 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor interacting protein 1 (Arfaptin 1), isoform CRA_b; ARFIP1 protein; cDNA FLJ53696, highly similar to Arfaptin-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0019904 [protein domain specific binding]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0050708 [regulation of protein secretion]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
Show all
 373 aa
41.7 kDa 		No 0
ARFIP1-202
ENSP00000479111
ENST00000618090
P53367 [Direct mapping]
Arfaptin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0019904 [protein domain specific binding]
GO:0032588 [trans-Golgi network membrane]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0050708 [regulation of protein secretion]
GO:0070273 [phosphatidylinositol-4-phosphate binding]
Show all
 341 aa
38.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.