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HHIP

GENERAL INFORMATION

Gene name

 HHIP

Gene description

 Hedgehog interacting protein

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (HUVEC TERT2, RH-30, TIME)
HPA (normal tissue):Tissue enhanced (lung)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA012616
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA012616

GENE INFORMATION

Gene name

 HHIP (HGNC Symbol)

Synonyms

 FLJ20992, HIP

Description

 Hedgehog interacting protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]

Chromosome

 4

Cytoband

 q31.21

Chromosome location (bp)

 144646021 - 144745271

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164161 (version 83.38)

Entrez gene

 64399

UniProt

 Q96QV1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96QV1

Antibodypedia

 HHIP antibodies

PROTEIN BROWSER
HHIP-001
HHIP-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HHIP-001
ENSP00000296575
ENST00000296575
Q96QV1 [Direct mapping]
Hedgehog-interacting protein
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007165 [signal transduction]
GO:0007224 [smoothened signaling pathway]
GO:0007405 [neuroblast proliferation]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0009953 [dorsal/ventral pattern formation]
GO:0009968 [negative regulation of signal transduction]
GO:0009986 [cell surface]
GO:0016901 [oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0048038 [quinone binding]
GO:0048705 [skeletal system morphogenesis]
GO:0055114 [oxidation-reduction process]
GO:0060170 [ciliary membrane]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0097108 [hedgehog family protein binding]
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 700 aa
78.9 kDa 		Yes 0
HHIP-002
ENSP00000408587
ENST00000434550
Q96QV1 [Direct mapping]
Hedgehog-interacting protein
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0008270 [zinc ion binding]
GO:0009968 [negative regulation of signal transduction]
GO:0016901 [oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0048038 [quinone binding]
GO:0048705 [skeletal system morphogenesis]
GO:0055114 [oxidation-reduction process]
GO:0060170 [ciliary membrane]
GO:0097108 [hedgehog family protein binding]
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 320 aa
36.4 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.