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ANAPC10

GENERAL INFORMATION

Gene name

 ANAPC10

Gene description

 Anaphase promoting complex subunit 10

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044547
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA044547

GENE INFORMATION

Gene name

 ANAPC10 (HGNC Symbol)

Synonyms

 APC10, DKFZP564L0562, DOC1

Description

 Anaphase promoting complex subunit 10 (HGNC Symbol)

Entrez gene summary

 ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

Chromosome

 4

Cytoband

 q31.21

Chromosome location (bp)

 144967112 - 145098541

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164162 (version 83.38)

Entrez gene

 10393

UniProt

 Q9UM13 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UM13

Antibodypedia

 ANAPC10 antibodies

PROTEIN BROWSER
ANAPC10-001
ANAPC10-002
ANAPC10-003
ANAPC10-004
ANAPC10-013
ANAPC10-014
ANAPC10-015
ANAPC10-016
ANAPC10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANAPC10-001
ENSP00000310071
ENST00000309439
Q9UM13 [Direct mapping]
Anaphase-promoting complex subunit 10
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 185 aa
21.3 kDa 		No 0
ANAPC10-002
ENSP00000403891
ENST00000451299
Q9UM13 [Direct mapping]
Anaphase-promoting complex subunit 10
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 185 aa
21.3 kDa 		No 0
ANAPC10-003
ENSP00000423995
ENST00000507656
Q9UM13 [Direct mapping]
Anaphase-promoting complex subunit 10
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 185 aa
21.3 kDa 		No 0
ANAPC10-004
ENSP00000423043
ENST00000514390
D6RA92 [Direct mapping]
Anaphase-promoting complex subunit 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005680 [anaphase-promoting complex]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
Show all
 158 aa
18 kDa 		No 0
ANAPC10-013
ENSP00000421609
ENST00000513054
D6RA92 [Direct mapping]
Anaphase-promoting complex subunit 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005680 [anaphase-promoting complex]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
Show all
 158 aa
18 kDa 		No 0
ANAPC10-014
ENSP00000424463
ENST00000502847
D6RB36 [Direct mapping]
Anaphase-promoting complex subunit 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 68 aa
7.5 kDa 		No 0
ANAPC10-015
ENSP00000423223
ENST00000504721
D6R9Q5 [Direct mapping]
Anaphase-promoting complex subunit 10
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 109 aa
12.3 kDa 		No 0
ANAPC10-016
ENSP00000425459
ENST00000512680
D6RD74 [Direct mapping]
Anaphase-promoting complex subunit 10
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 126 aa
14.2 kDa 		No 0
ANAPC10-201
ENSP00000478501
ENST00000613466
Q9UM13 [Direct mapping]
Anaphase-promoting complex subunit 10
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
Show all
 185 aa
21.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.