Expression of SLC45A2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SLC45A2

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SLC45A2
Gene description	Solute carrier family 45, member 2
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (melanoma)
HPA (cell line):	Cell line enriched (SK-MEL-30)
HPA (normal tissue):	Tissue enhanced (skin, testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SLC45A2 (HGNC Symbol)
Synonyms	AIM-1, MATP, OCA4
Description	Solute carrier family 45, member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	5
Cytoband	p13.2
Chromosome location (bp)	33944616 - 33984730
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164175 (version 83.38)
Entrez gene	51151
UniProt	Q9UMX9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UMX9
Antibodypedia	SLC45A2 antibodies

PROTEIN BROWSER

SLC45A2-001	SLC45A2-002	SLC45A2-003	SLC45A2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC45A2-001 ENSP00000296589 ENST00000296589	Q9UMX9 [Direct mapping] Membrane-associated transporter protein A0A076YIB8 [Target identity:100%; Query identity:100%] SLC45A2; Solute carrier family 45, member 2, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0007601 [visual perception] GO:0016021 [integral component of membrane] GO:0033162 [melanosome membrane] GO:0042438 [melanin biosynthetic process] GO:0048066 [developmental pigmentation] GO:0050896 [response to stimulus] Show all	530 aa 58.3 kDa	No	>9
SLC45A2-002 ENSP00000371534 ENST00000382102	Q9UMX9 [Direct mapping] Membrane-associated transporter protein Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0007601 [visual perception] GO:0016021 [integral component of membrane] GO:0033162 [melanosome membrane] GO:0042438 [melanin biosynthetic process] GO:0050896 [response to stimulus] Show all	460 aa 51.2 kDa	No	>9
SLC45A2-003 ENSP00000421100 ENST00000509381	D6RGY6 [Direct mapping] Membrane-associated transporter protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	243 aa 26.7 kDa	No	4
SLC45A2-005 ENSP00000424010 ENST00000510600	D6RBP8 [Direct mapping] Membrane-associated transporter protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	246 aa 27.3 kDa	No	5

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.