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Cell line enhanced (LHCN-M2, TIME, U-2 OS, U-87 MG)
HPA (normal tissue):
Tissue enhanced (cerebral cortex)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic and extracellular expression in most tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Moderate cytoplasmic and nuclear immunoreactivity was observed in most cancer tissues. A few cases of testicular cancers, malignant gliomas and melanomas were strongly stained. Several cases of malignant lymphomas and squamous cell carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
EDIL3 (HGNC Symbol)
Synonyms
DEL1
Description
EGF-like repeats and discoidin I-like domains 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]
O43854 [Direct mapping] EGF-like repeat and discoidin I-like domain-containing protein 3
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)