Expression of ADGRV1 in cancer - Summary - The Human Protein Atlas

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ADGRV1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADGRV1
Gene description	Adhesion G protein-coupled receptor V1
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, SCLC-21H)
HPA (normal tissue):	Group enriched (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in adrenal gland. Low expression in other tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA067503
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA067503

GENE INFORMATION
Gene name	ADGRV1 (HGNC Symbol)
Synonyms	DKFZp761P0710, FEB4, GPR98, KIAA0686, MASS1, USH2C, VLGR1
Description	Adhesion G protein-coupled receptor V1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q14.3
Chromosome location (bp)	90529344 - 91164221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164199 (version 83.38)
Entrez gene	84059
UniProt	Q8WXG9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXG9
Antibodypedia	ADGRV1 antibodies

PROTEIN BROWSER

ADGRV1-001	ADGRV1-002	ADGRV1-003	ADGRV1-004	ADGRV1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRV1-001 ENSP00000384582 ENST00000405460	Q8WXG9 [Direct mapping] G-protein coupled receptor 98 Show all	Transporters Electrochemical Potential-driven transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007399 [nervous system development] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0032420 [stereocilium] GO:0043235 [receptor complex] GO:0045202 [synapse] GO:0045494 [photoreceptor cell maintenance] GO:0048496 [maintenance of organ identity] GO:0050877 [neurological system process] GO:0050953 [sensory perception of light stimulus] GO:0070062 [extracellular exosome] Show all	6306 aa 693.1 kDa	Yes	7
ADGRV1-002 ENSP00000424736 ENST00000504142	H0Y9Q4 [Direct mapping] Protein ADGRV1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007154 [cell communication] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	1055 aa 116.7 kDa	No	0
ADGRV1-003 ENSP00000422153 ENST00000509621	H0Y8U6 [Direct mapping] Protein ADGRV1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007154 [cell communication] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	1608 aa 176.7 kDa	No	0
ADGRV1-004 ENSP00000392618 ENST00000425867	Q8WXG9 [Direct mapping] G-protein coupled receptor 98 Show all	Transporters Electrochemical Potential-driven transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007399 [nervous system development] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0043235 [receptor complex] GO:0045494 [photoreceptor cell maintenance] GO:0048496 [maintenance of organ identity] GO:0050877 [neurological system process] GO:0050953 [sensory perception of light stimulus] GO:0070062 [extracellular exosome] Show all	1967 aa 217.2 kDa	Yes	7
ADGRV1-006 ENSP00000425936 ENST00000508842	D6RIF0 [Direct mapping] Protein ADGRV1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007154 [cell communication] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	148 aa 16 kDa	Yes	0

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