Expression of PRRC1 in cancer - Summary - The Human Protein Atlas

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PRRC1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRRC1
Gene description	Proline-rich coiled-coil 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA039212
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039212

GENE INFORMATION
Gene name	PRRC1 (HGNC Symbol)
Synonyms	FLJ32875
Description	Proline-rich coiled-coil 1 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q23.2
Chromosome location (bp)	127517609 - 127555089
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164244 (version 83.38)
Entrez gene	133619
UniProt	Q96M27 (UniProt - Evidence at protein level)
neXtProt	NX_Q96M27
Antibodypedia	PRRC1 antibodies

PROTEIN BROWSER

PRRC1-001	PRRC1-002	PRRC1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRRC1-001 ENSP00000296666 ENST00000296666	Q96M27 [Direct mapping] Protein PRRC1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] Show all	445 aa 46.7 kDa	No	0
PRRC1-002 ENSP00000392873 ENST00000442138	Q96M27 [Direct mapping] Protein PRRC1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] Show all	418 aa 44.1 kDa	No	1
PRRC1-003 ENSP00000421965 ENST00000512635	Q96M27 [Direct mapping] Protein PRRC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] Show all	462 aa 48.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.