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ESM1

GENERAL INFORMATION

Gene name

 ESM1

Gene description

 Endothelial cell-specific molecule 1

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (renal cancer)
HPA (cell line):Group enriched (HUVEC TERT2, TIME)
HPA (normal tissue):Tissue enhanced (kidney, thyroid gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and renal cancer (unfavourable).
Cervical cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ESM1

Synonyms

Description

 Endothelial cell-specific molecule 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Chromosome

 5

Cytoband

 q11.2

Chromosome location (bp)

 54977864 - 55022671

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164283 (version 83.38)

Entrez gene

 11082

UniProt

 Q9NQ30 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQ30

Antibodypedia

 ESM1 antibodies

PROTEIN BROWSER
ESM1-001
ESM1-002
ESM1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ESM1-001
ENSP00000370812
ENST00000381405
Q9NQ30 [Direct mapping]
Endothelial cell-specific molecule 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0001525 [angiogenesis]
GO:0001558 [regulation of cell growth]
GO:0002040 [sprouting angiogenesis]
GO:0005171 [hepatocyte growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0008284 [positive regulation of cell proliferation]
GO:1902204 [positive regulation of hepatocyte growth factor receptor signaling pathway]
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 184 aa
20.1 kDa 		Yes 0
ESM1-002
ENSP00000370810
ENST00000381403
Q9NQ30 [Direct mapping]
Endothelial cell-specific molecule 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001525 [angiogenesis]
GO:0001558 [regulation of cell growth]
GO:0002040 [sprouting angiogenesis]
GO:0005171 [hepatocyte growth factor receptor binding]
GO:0005178 [integrin binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0008284 [positive regulation of cell proliferation]
GO:1902204 [positive regulation of hepatocyte growth factor receptor signaling pathway]
Show all
 134 aa
14.5 kDa 		Yes 0
ESM1-004
ENSP00000471642
ENST00000601836
M0R154 [Direct mapping]
Endothelial cell-specific molecule 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001558 [regulation of cell growth]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
Show all
 89 aa
9.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.