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GRPEL2

GENERAL INFORMATION

Gene name

 GRPEL2

Gene description

 GrpE-like 2, mitochondrial (E. coli)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (esophagus)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA018173 , HPA023211
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), colorectal cancer (favourable), endometrial cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
Endometrial cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA018173
HPA023211

GENE INFORMATION

Gene name

 GRPEL2 (HGNC Symbol)

Synonyms

 DKFZp451C205, FLJ23713, Mt-GrpE#2

Description

 GrpE-like 2, mitochondrial (E. coli) (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 149345430 - 149354583

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164284 (version 83.38)

Entrez gene

 134266

UniProt

 Q8TAA5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TAA5

Antibodypedia

 GRPEL2 antibodies

PROTEIN BROWSER
GRPEL2-001
GRPEL2-002
GRPEL2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRPEL2-001
ENSP00000329558
ENST00000329271
Q8TAA5 [Direct mapping]
GrpE protein homolog 2, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000774 [adenyl-nucleotide exchange factor activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006457 [protein folding]
GO:0006626 [protein targeting to mitochondrion]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0050790 [regulation of catalytic activity]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
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 225 aa
25.4 kDa 		No 0
GRPEL2-002
ENSP00000397302
ENST00000416916
Q8TAA5 [Direct mapping]
GrpE protein homolog 2, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000774 [adenyl-nucleotide exchange factor activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006457 [protein folding]
GO:0006626 [protein targeting to mitochondrion]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0050790 [regulation of catalytic activity]
GO:0051087 [chaperone binding]
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 122 aa
14.3 kDa 		No 0
GRPEL2-003
ENSP00000426331
ENST00000513661
D6RGI6 [Direct mapping]
GrpE protein homolog 2, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000774 [adenyl-nucleotide exchange factor activity]
GO:0005739 [mitochondrion]
GO:0006457 [protein folding]
GO:0042803 [protein homodimerization activity]
GO:0050790 [regulation of catalytic activity]
GO:0051087 [chaperone binding]
Show all
 128 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.