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SERINC5

GENERAL INFORMATION

Gene name

 SERINC5

Gene description

 Serine incorporator 5

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA037898 , HPA037899
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037898
HPA037899

GENE INFORMATION

Gene name

 SERINC5 (HGNC Symbol)

Synonyms

 C5orf12, TPO1

Description

 Serine incorporator 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q14.1

Chromosome location (bp)

 80111651 - 80256079

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164300 (version 83.38)

Entrez gene

 256987

UniProt

 Q86VE9 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86VE9

Antibodypedia

 SERINC5 antibodies

PROTEIN BROWSER
SERINC5-001
SERINC5-008
SERINC5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERINC5-001
ENSP00000426237
ENST00000507668
Q86VE9 [Direct mapping]
Serine incorporator 5
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006658 [phosphatidylserine metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0008654 [phospholipid biosynthetic process]
GO:0009597 [detection of virus]
GO:0015194 [L-serine transmembrane transporter activity]
GO:0015825 [L-serine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0042552 [myelination]
GO:0043209 [myelin sheath]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
GO:1904219 [positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity]
GO:1904222 [positive regulation of serine C-palmitoyltransferase activity]
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 461 aa
51.3 kDa 		No >9
SERINC5-008
ENSP00000426134
ENST00000509193
Q86VE9 [Direct mapping]
Serine incorporator 5
D6RHG7 [Direct mapping]
Serine incorporator 5
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006658 [phosphatidylserine metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0008654 [phospholipid biosynthetic process]
GO:0009597 [detection of virus]
GO:0015194 [L-serine transmembrane transporter activity]
GO:0015825 [L-serine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0042552 [myelination]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
GO:1904219 [positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity]
GO:1904222 [positive regulation of serine C-palmitoyltransferase activity]
Show all
 420 aa
46.6 kDa 		No 9
SERINC5-201
ENSP00000420863
ENST00000512721
A0A0A0MTB0 [Direct mapping]
Serine incorporator 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006658 [phosphatidylserine metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0015194 [L-serine transmembrane transporter activity]
GO:0015825 [L-serine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0042552 [myelination]
Show all
 417 aa
46.3 kDa 		No 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.