Expression of CAGE1 in cancer - Summary - The Human Protein Atlas

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CAGE1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CAGE1
Gene description	Cancer antigen 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA029832
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029832

Cancer	Cancer staining
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Weak to moderate cytoplasmic positivity was observed in most malignancies. A few colorectal cancers showed strong cytoplasmic positivity. Several malignant gliomas, liver and cervical cancers were negative.

GENE INFORMATION
Gene name	CAGE1 (HGNC Symbol)
Synonyms	bA69L16.7, CT95, CTAG3
Description	Cancer antigen 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p24.3
Chromosome location (bp)	7326656 - 7389743
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164304 (version 83.38)
Entrez gene	285782
UniProt	Q8TC20 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TC20
Antibodypedia	CAGE1 antibodies

PROTEIN BROWSER

CAGE1-001	CAGE1-002	CAGE1-003	CAGE1-004	CAGE1-005	CAGE1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAGE1-001 ENSP00000425493 ENST00000502583	Q8TC20 [Direct mapping] Cancer-associated gene 1 protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	839 aa 97.7 kDa	No	0
CAGE1-002 ENSP00000296742 ENST00000296742	Q8TC20 [Direct mapping] Cancer-associated gene 1 protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	641 aa 74.7 kDa	No	0
CAGE1-003 ENSP00000338107 ENST00000338150	Q8TC20 [Direct mapping] Cancer-associated gene 1 protein Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] Show all	824 aa 95.4 kDa	No	0
CAGE1-004 ENSP00000369250 ENST00000379918	E7EUJ7 [Direct mapping] Cancer-associated gene 1 protein Show all	Predicted intracellular proteins Show all		817 aa 95.1 kDa	No	0
CAGE1-005 ENSP00000423789 ENST00000512691	D6RCC6 [Direct mapping] Cancer-associated gene 1 protein Show all	Predicted intracellular proteins Show all		558 aa 65.1 kDa	No	0
CAGE1-008 ENSP00000427583 ENST00000512086	Q8TC20 [Direct mapping] Cancer-associated gene 1 protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	777 aa 90.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.