Expression of TMEM174 in cancer - Summary - The Human Protein Atlas

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TMEM174

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM174
Gene description	Transmembrane protein 174
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (renal cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Luminal membranous expression in proximal renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA037975
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037975

GENE INFORMATION
Gene name	TMEM174 (HGNC Symbol)
Synonyms	FLJ31268, MGC13034
Description	Transmembrane protein 174 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q13.2
Chromosome location (bp)	73173195 - 73175143
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164325 (version 83.38)
Entrez gene	134288
UniProt	Q8WUU8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WUU8
Antibodypedia	TMEM174 antibodies

PROTEIN BROWSER

TMEM174-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM174-001 ENSP00000296776 ENST00000296776	Q8WUU8 [Direct mapping] Transmembrane protein 174 A0A024RAN0 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	243 aa 26.3 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.