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CARTPT

GENERAL INFORMATION

Gene name

 CARTPT

Gene description

 CART prepropeptide

Protein class

 FDA approved drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adrenal gland)
GTEx:Tissue enriched (hypothalamus)
FANTOM5:Tissue enhanced (brain, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External RNA data suggests expression in hypothalamus.

Reliability score

 Uncertain based on 1 antibody.
HPA046278
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION

Gene name

 CARTPT (HGNC Symbol)

Synonyms

 CART

Description

 CART prepropeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in this gene are associated with susceptibility to obesity.[provided by RefSeq, Nov 2009]

Chromosome

 5

Cytoband

 q13.2

Chromosome location (bp)

 71719163 - 71721048

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164326 (version 83.38)

Entrez gene

 9607

UniProt

 Q16568 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16568

Antibodypedia

 CARTPT antibodies

PROTEIN BROWSER
CARTPT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CARTPT-001
ENSP00000296777
ENST00000296777
Q16568 [Direct mapping]
Cocaine- and amphetamine-regulated transcript protein CART(1-39) CART(42-89)
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001678 [cellular glucose homeostasis]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0008343 [adult feeding behavior]
GO:0009267 [cellular response to starvation]
GO:0030141 [secretory granule]
GO:0032099 [negative regulation of appetite]
GO:0032812 [positive regulation of epinephrine secretion]
GO:0032922 [circadian regulation of gene expression]
GO:0045671 [negative regulation of osteoclast differentiation]
GO:0045777 [positive regulation of blood pressure]
GO:0045779 [negative regulation of bone resorption]
GO:0046850 [regulation of bone remodeling]
GO:0050796 [regulation of insulin secretion]
GO:0051971 [positive regulation of transmission of nerve impulse]
GO:0070093 [negative regulation of glucagon secretion]
GO:0070253 [somatostatin secretion]
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 116 aa
12.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.