Cell atlas - UTP15 - The Human Protein Atlas

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UTP15

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Nucleoli

Human cell
	Endoplasmic Reticulum
	Nucleoli

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GENERAL INFORMATION
Gene name	UTP15
Gene description	UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli & endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported), Endoplasmic reticulum (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA044697
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli & endoplasmic reticulum.

Main location

Nucleoli (supported), Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044697	U-2 OS	Nucleoli	Intensity	Intensity
	HPA044697	U-2 OS	Endoplasmic reticulum	Intensity	Intensity
	HPA044697	U-251 MG	Nucleoli
	HPA044697	U-251 MG	Endoplasmic reticulum

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA044697	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. UTP15 is mostly expressed at the G1/S checkpoint, and during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Endoplasmic reticulum, Nucleoli

GENE INFORMATION
Gene name	UTP15 (HGNC Symbol)
Synonyms	FLJ12787, FLJ23637, NET21
Description	UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q13.2
Chromosome location (bp)	73565443 - 73583377
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164338 (version 83.38)
Entrez gene	84135
UniProt	Q8TED0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TED0
Antibodypedia	UTP15 antibodies

PROTEIN BROWSER

UTP15-001	UTP15-002	UTP15-003	UTP15-004	UTP15-007	UTP15-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UTP15-001 ENSP00000296792 ENST00000296792	Q8TED0 [Direct mapping] U3 small nucleolar RNA-associated protein 15 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006364 [rRNA processing] GO:0030054 [cell junction] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034455 [t-UTP complex] GO:0044822 [poly(A) RNA binding] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] Show all	518 aa 58.4 kDa	No	0
UTP15-002 ENSP00000421669 ENST00000509005	H0Y8P4 [Direct mapping] U3 small nucleolar RNA-associated protein 15 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034455 [t-UTP complex] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] Show all	545 aa 61.3 kDa	No	0
UTP15-003 ENSP00000424609 ENST00000508491	Q8TED0 [Direct mapping] U3 small nucleolar RNA-associated protein 15 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006364 [rRNA processing] GO:0030054 [cell junction] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034455 [t-UTP complex] GO:0044822 [poly(A) RNA binding] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] Show all	499 aa 56.4 kDa	No	0
UTP15-004 ENSP00000424902 ENST00000513824	D6RF65 [Direct mapping] U3 small nucleolar RNA-associated protein 15 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034455 [t-UTP complex] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] Show all	65 aa 7.4 kDa	No	0
UTP15-007 ENSP00000424334 ENST00000508686		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		7 aa 0.8 kDa	No	0
UTP15-201 ENSP00000440796 ENST00000543251	Q8TED0 [Direct mapping] U3 small nucleolar RNA-associated protein 15 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006364 [rRNA processing] GO:0030054 [cell junction] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034455 [t-UTP complex] GO:0044822 [poly(A) RNA binding] GO:0045943 [positive regulation of transcription from RNA polymerase I promoter] Show all	328 aa 37 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.