Expression of NSA2 in cancer - Summary - The Human Protein Atlas

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NSA2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NSA2
Gene description	NSA2 ribosome biogenesis homolog
Protein class	Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043487
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043487

GENE INFORMATION
Gene name	NSA2 (HGNC Symbol)
Synonyms	FLJ94393, HCLG1, HUSSY-29, TINP1
Description	NSA2 ribosome biogenesis homolog (HGNC Symbol)
Entrez gene summary	This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]
Chromosome	5
Cytoband	q13.3
Chromosome location (bp)	74766991 - 74780113
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164346 (version 83.38)
Entrez gene	10412
UniProt	O95478 (UniProt - Evidence at protein level)
neXtProt	NX_O95478
Antibodypedia	NSA2 antibodies

PROTEIN BROWSER

NSA2-001	NSA2-003	NSA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NSA2-001 ENSP00000483484 ENST00000610426	O95478 [Direct mapping] Ribosome biogenesis protein NSA2 homolog Q5J7U2 [Target identity:100%; Query identity:100%] TGF beta-inducible nuclear protein 1; TGF-beta inducible nuclear protein; cDNA, FLJ94393, Homo sapiens TGF beta-inducible nuclear protein 1 (TINP1), mRNA Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0030529 [ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] Show all	260 aa 30.1 kDa	No	0
NSA2-003 ENSP00000427266 ENST00000515524	H0YAI9 [Direct mapping] Ribosome biogenesis protein NSA2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.4 kDa	No	0
NSA2-201 ENSP00000296802 ENST00000296802	A0A0A0MQZ6 [Direct mapping] Ribosome biogenesis protein NSA2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		189 aa 22.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.