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Malignant tissues displayed moderate cytoplasmic positivity with occasional nuclear or membranous staining. A few cases of testicular cancers showed strong staining. Several renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
GFM2 (HGNC Symbol)
Synonyms
EFG2, FLJ21661
Description
G elongation factor, mitochondrial 2 (HGNC Symbol)
Entrez gene summary
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]