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TERT

GENERAL INFORMATION

Gene name

 TERT

Gene description

 Telomerase reverse transcriptase

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (ASC TERT1, BJ hTERT+, LHCN-M2, TIME)
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TERT (HGNC Symbol)

Synonyms

 EST2, hEST2, TCS1, TP2, TRT

Description

 Telomerase reverse transcriptase (HGNC Symbol)

Entrez gene summary

 Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 p15.33

Chromosome location (bp)

 1253147 - 1295069

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164362 (version 83.38)

Entrez gene

 7015

UniProt

 O14746 (UniProt - Evidence at protein level)

neXtProt

 NX_O14746

Antibodypedia

 TERT antibodies

PROTEIN BROWSER
TERT-001
TERT-005
TERT-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TERT-001
ENSP00000309572
ENST00000310581
O14746 [Direct mapping]
Telomerase reverse transcriptase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000333 [telomerase catalytic core complex]
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0001172 [transcription, RNA-templated]
GO:0001223 [transcription coactivator binding]
GO:0003677 [DNA binding]
GO:0003720 [telomerase activity]
GO:0003721 [telomeric template RNA reverse transcriptase activity]
GO:0003723 [RNA binding]
GO:0003964 [RNA-directed DNA polymerase activity]
GO:0003968 [RNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006278 [RNA-dependent DNA replication]
GO:0007004 [telomere maintenance via telomerase]
GO:0007005 [mitochondrion organization]
GO:0010629 [negative regulation of gene expression]
GO:0016605 [PML body]
GO:0016779 [nucleotidyltransferase activity]
GO:0022616 [DNA strand elongation]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031379 [RNA-directed RNA polymerase complex]
GO:0032774 [RNA biosynthetic process]
GO:0042162 [telomeric DNA binding]
GO:0042635 [positive regulation of hair cycle]
GO:0042645 [mitochondrial nucleoid]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0070034 [telomeric RNA binding]
GO:0071456 [cellular response to hypoxia]
GO:0071897 [DNA biosynthetic process]
GO:0090399 [replicative senescence]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:1903704 [negative regulation of production of siRNA involved in RNA interference]
GO:1990572 [TERT-RMRP complex]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000773 [negative regulation of cellular senescence]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 1132 aa
127 kDa 		No 2
TERT-005
ENSP00000334346
ENST00000334602
O14746 [Direct mapping]
Telomerase reverse transcriptase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000333 [telomerase catalytic core complex]
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0001172 [transcription, RNA-templated]
GO:0001223 [transcription coactivator binding]
GO:0003677 [DNA binding]
GO:0003720 [telomerase activity]
GO:0003721 [telomeric template RNA reverse transcriptase activity]
GO:0003723 [RNA binding]
GO:0003964 [RNA-directed DNA polymerase activity]
GO:0003968 [RNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0006278 [RNA-dependent DNA replication]
GO:0007004 [telomere maintenance via telomerase]
GO:0007005 [mitochondrion organization]
GO:0010629 [negative regulation of gene expression]
GO:0016605 [PML body]
GO:0016779 [nucleotidyltransferase activity]
GO:0022616 [DNA strand elongation]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031379 [RNA-directed RNA polymerase complex]
GO:0032774 [RNA biosynthetic process]
GO:0042162 [telomeric DNA binding]
GO:0042645 [mitochondrial nucleoid]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0070034 [telomeric RNA binding]
GO:0071456 [cellular response to hypoxia]
GO:0071897 [DNA biosynthetic process]
GO:0090399 [replicative senescence]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:1903704 [negative regulation of production of siRNA involved in RNA interference]
GO:1990572 [TERT-RMRP complex]
GO:2000773 [negative regulation of cellular senescence]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 1069 aa
120 kDa 		No 2
TERT-006
ENSP00000426042
ENST00000508104
O14746 [Direct mapping]
Telomerase reverse transcriptase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Potential drug targets
Show all
GO:0000049 [tRNA binding]
GO:0000333 [telomerase catalytic core complex]
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0001172 [transcription, RNA-templated]
GO:0001223 [transcription coactivator binding]
GO:0003677 [DNA binding]
GO:0003720 [telomerase activity]
GO:0003721 [telomeric template RNA reverse transcriptase activity]
GO:0003723 [RNA binding]
GO:0003964 [RNA-directed DNA polymerase activity]
GO:0003968 [RNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0006278 [RNA-dependent DNA replication]
GO:0007004 [telomere maintenance via telomerase]
GO:0007005 [mitochondrion organization]
GO:0010629 [negative regulation of gene expression]
GO:0016605 [PML body]
GO:0016779 [nucleotidyltransferase activity]
GO:0022616 [DNA strand elongation]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031379 [RNA-directed RNA polymerase complex]
GO:0032774 [RNA biosynthetic process]
GO:0042162 [telomeric DNA binding]
GO:0042645 [mitochondrial nucleoid]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0070034 [telomeric RNA binding]
GO:0071456 [cellular response to hypoxia]
GO:0071897 [DNA biosynthetic process]
GO:0090399 [replicative senescence]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:1903704 [negative regulation of production of siRNA involved in RNA interference]
GO:1990572 [TERT-RMRP complex]
GO:2000773 [negative regulation of cellular senescence]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 807 aa
90.2 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.