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SLC6A18

GENERAL INFORMATION

Gene name

 SLC6A18

Gene description

 Solute carrier family 6 (neutral amino acid transporter), member 18

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Tissue enriched (kidney)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Expression in luminal membrane, kidney. Additional cytoplasmic and membranous expression in epididymis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA011885
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 SLC6A18 (HGNC Symbol)

Synonyms

 FLJ31236, Xtrp2

Description

 Solute carrier family 6 (neutral amino acid transporter), member 18 (HGNC Symbol)

Entrez gene summary

 The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010]

Chromosome

 5

Cytoband

 p15.33

Chromosome location (bp)

 1225355 - 1246189

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164363 (version 83.38)

Entrez gene

 348932

UniProt

 Q96N87 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96N87

Antibodypedia

 SLC6A18 antibodies

PROTEIN BROWSER
SLC6A18-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC6A18-001
ENSP00000323549
ENST00000324642
Q96N87 [Direct mapping]
Sodium-dependent neutral amino acid transporter B(0)AT3
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
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GO:0003333 [amino acid transmembrane transport]
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006836 [neurotransmitter transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0031526 [brush border membrane]
GO:0055085 [transmembrane transport]
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 628 aa
70.9 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.