Cell atlas - CCDC127 - The Human Protein Atlas

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CCDC127

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CCDC127
Gene description	Coiled-coil domain containing 127
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli (fibrillar center).
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nucleoli fibrillar center (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA045052
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli (fibrillar center).

Main location

Nucleus (supported), Nucleoli fibrillar center (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045052	A-431	Nucleus
	HPA045052	A-431	Nucleoli fibrillar center
	HPA045052	U-2 OS	Nucleus
	HPA045052	U-2 OS	Nucleoli fibrillar center
	HPA045052	U-251 MG	Nucleus
	HPA045052	U-251 MG	Nucleoli fibrillar center

GENE INFORMATION
Gene name	CCDC127 (HGNC Symbol)
Synonyms	FLJ25701
Description	Coiled-coil domain containing 127 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	196871 - 218215
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164366 (version 83.38)
Entrez gene	133957
UniProt	Q96BQ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BQ5
Antibodypedia	CCDC127 antibodies

PROTEIN BROWSER

CCDC127-001	CCDC127-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC127-001 ENSP00000296824 ENST00000296824	Q96BQ5 [Direct mapping] Coiled-coil domain-containing protein 127 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		260 aa 30.8 kDa	No	0
CCDC127-002 ENSP00000411206 ENST00000441693	D6R9R2 [Direct mapping] Coiled-coil domain-containing protein 127 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	69 aa 8.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.