Expression of ACSL6 in cancer - Summary - The Human Protein Atlas

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ACSL6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACSL6
Gene description	Acyl-CoA synthetase long-chain family member 6
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, glioma, liver cancer)
HPA (cell line):	Group enriched (SCLC-21H, U-937)
HPA (normal tissue):	Group enriched (bone marrow, cerebral cortex, parathyroid gland, seminal vesicle, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA040470
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, glioma, liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040470

GENE INFORMATION
Gene name	ACSL6 (HGNC Symbol)
Synonyms	ACS2, FACL6, KIAA0837, LACS2, LACS5
Description	Acyl-CoA synthetase long-chain family member 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	131949973 - 132012243
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164398 (version 83.38)
Entrez gene	23305
UniProt	Q9UKU0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UKU0
Antibodypedia	ACSL6 antibodies

PROTEIN BROWSER

ACSL6-001	ACSL6-002	ACSL6-003	ACSL6-004	ACSL6-005	ACSL6-008	ACSL6-009	ACSL6-011	ACSL6-012	ACSL6-016	ACSL6-017	ACSL6-018	ACSL6-019	ACSL6-201	ACSL6-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSL6-001 ENSP00000368566 ENST00000379264	Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	722 aa 80.6 kDa	No	3
ACSL6-002 ENSP00000368548 ENST00000379246	Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	708 aa 79 kDa	No	2
ACSL6-003 ENSP00000368557 ENST00000379255	Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	622 aa 69.2 kDa	No	0
ACSL6-004 ENSP00000368542 ENST00000379240	Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	697 aa 77.8 kDa	No	2
ACSL6-005 ENSP00000397507 ENST00000434099	C9J8C7 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	365 aa 40.8 kDa	No	0
ACSL6-008 ENSP00000368546 ENST00000379244	Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	697 aa 77.7 kDa	No	2
ACSL6-009 ENSP00000296869 ENST00000296869	Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	722 aa 80.5 kDa	No	3
ACSL6-011 ENSP00000398423 ENST00000430403	C9J3Z0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	213 aa 23.9 kDa	No	1
ACSL6-012 ENSP00000388424 ENST00000419502	C9JK59 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	152 aa 17 kDa	No	1
ACSL6-016 ENSP00000394810 ENST00000414078	C9JPA5 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	135 aa 15.2 kDa	No	1
ACSL6-017 ENSP00000389189 ENST00000441995	C9JT10 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		100 aa 11.3 kDa	No	0
ACSL6-018 ENSP00000413329 ENST00000431707	E7ERD7 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	677 aa 75.2 kDa	No	0
ACSL6-019 ENSP00000398381 ENST00000416557	C9J4I1 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	144 aa 16.1 kDa	No	1
ACSL6-201 ENSP00000349608 ENST00000357096	Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	622 aa 69.2 kDa	No	0
ACSL6-202 ENSP00000442124 ENST00000543479	Q9UKU0 [Direct mapping] Long-chain-fatty-acid--CoA ligase 6 Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001676 [long-chain fatty acid metabolic process] GO:0003824 [catalytic activity] GO:0004467 [long-chain fatty acid-CoA ligase activity] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0005778 [peroxisomal membrane] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006637 [acyl-CoA metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019432 [triglyceride biosynthetic process] GO:0019899 [enzyme binding] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	712 aa 79.1 kDa	No	2

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The Human Protein Atlas

The Human Protein Atlas project is funded
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