Tissue expression of SLC35A1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC35A1
Gene description	Solute carrier family 35 (CMP-sialic acid transporter), member A1
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Not detected
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC35A1 (HGNC Symbol)
Synonyms	CMPST, hCST
Description	Solute carrier family 35 (CMP-sialic acid transporter), member A1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
Chromosome	6
Cytoband	q15
Chromosome location (bp)	87470623 - 87512336
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164414 (version 83.38)
Entrez gene	10559
UniProt	P78382 (UniProt - Evidence at transcript level)
neXtProt	NX_P78382
Antibodypedia	SLC35A1 antibodies

PROTEIN BROWSER

SLC35A1-001	SLC35A1-201	SLC35A1-202	SLC35A1-203	SLC35A1-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35A1-001 ENSP00000358565 ENST00000369552	P78382 [Direct mapping] CMP-sialic acid transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005456 [CMP-N-acetylneuraminate transmembrane transporter activity] GO:0005794 [Golgi apparatus] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006464 [cellular protein modification process] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015782 [CMP-N-acetylneuraminate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:1901679 [nucleotide transmembrane transport] Show all	337 aa 36.8 kDa	No	8
SLC35A1-201 ENSP00000358569 ENST00000369556	P78382 [Direct mapping] CMP-sialic acid transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005456 [CMP-N-acetylneuraminate transmembrane transporter activity] GO:0005794 [Golgi apparatus] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006464 [cellular protein modification process] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015782 [CMP-N-acetylneuraminate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:1901679 [nucleotide transmembrane transport] Show all	278 aa 29.9 kDa	No	6
SLC35A1-202 ENSP00000358570 ENST00000369557	Q5W1L7 [Direct mapping] CMP-sialic acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:1901679 [nucleotide transmembrane transport] Show all	189 aa 20.8 kDa	No	5
SLC35A1-203 ENSP00000438603 ENST00000544441	Q5W1L6 [Direct mapping] CMP-sialic acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] Show all	65 aa 7.2 kDa	No	2
SLC35A1-204 ENSP00000479535 ENST00000622775	A0A087WVM1 [Direct mapping] CMP-sialic acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005338 [nucleotide-sugar transmembrane transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0008643 [carbohydrate transport] GO:0015780 [nucleotide-sugar transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:1901679 [nucleotide transmembrane transport] Show all	189 aa 21.4 kDa	No	3