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Most cancer tissues showed weak cytoplasmic staining or were negative. Few lymphomas, ovarian and pancreatic cancers were moderately positive. Additional membranous staining was observed in colorectal and urothelial cancers.
A majority of cancer tissues showed weak to moderate cytoplasmic staining. Several cases of lymphomas, hepatocellular tumors of the liver, skin, renal and testicular cancers were negative.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]