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Strong nuclear immunoreactivity was observed in cancer tissues. Additional cytoplasmic positivity was observed in hepatocellular carcinomas.
GENE INFORMATION
Gene name
CITED2 (HGNC Symbol)
Synonyms
MRG1
Description
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]