Expression of DCBLD1 in cancer - Summary - The Human Protein Atlas

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DCBLD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DCBLD1
Gene description	Discoidin, CUB and LCCL domain containing 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA059667
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059667

GENE INFORMATION
Gene name	DCBLD1 (HGNC Symbol)
Synonyms	dJ94G16.1, MGC46341
Description	Discoidin, CUB and LCCL domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q22.1
Chromosome location (bp)	117453817 - 117569858
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164465 (version 83.38)
Entrez gene	285761
UniProt	Q8N8Z6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N8Z6
Antibodypedia	DCBLD1 antibodies

PROTEIN BROWSER

DCBLD1-001	DCBLD1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCBLD1-001 ENSP00000342422 ENST00000338728	Q8N8Z6 [Direct mapping] Discoidin, CUB and LCCL domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070492 [oligosaccharide binding] Show all	715 aa 77.9 kDa	Yes	1
DCBLD1-002 ENSP00000296955 ENST00000296955	Q8N8Z6 [Direct mapping] Discoidin, CUB and LCCL domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070492 [oligosaccharide binding] Show all	539 aa 59.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.