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IL31RA

GENERAL INFORMATION

Gene name

 IL31RA

Gene description

 Interleukin 31 receptor A

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 IL31RA (HGNC Symbol)

Synonyms

 CRL, CRL3, GLM-R, Glmr, IL-31RA

Description

 Interleukin 31 receptor A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Chromosome

 5

Cytoband

 q11.2

Chromosome location (bp)

 55851379 - 55922853

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164509 (version 83.38)

Entrez gene

 133396

UniProt

 Q8NI17 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NI17

Antibodypedia

 IL31RA antibodies

PROTEIN BROWSER
IL31RA-001
IL31RA-002
IL31RA-003
IL31RA-004
IL31RA-005
IL31RA-201
IL31RA-202
IL31RA-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL31RA-001
ENSP00000415900
ENST00000447346
Q8NI17 [Direct mapping]
Interleukin-31 receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0002067 [glandular epithelial cell differentiation]
GO:0002438 [acute inflammatory response to antigenic stimulus]
GO:0003713 [transcription coactivator activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0008284 [positive regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019955 [cytokine binding]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0035745 [T-helper 2 cell cytokine production]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042592 [homeostatic process]
GO:0043031 [negative regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0098542 [defense response to other organism]
Show all
 764 aa
86.5 kDa 		No 1
IL31RA-002
ENSP00000380046
ENST00000396834
Q8NI17 [Direct mapping]
Interleukin-31 receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0003713 [transcription coactivator activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019955 [cytokine binding]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042592 [homeostatic process]
GO:0043031 [negative regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 662 aa
74.9 kDa 		Yes 1
IL31RA-003
ENSP00000351935
ENST00000359040
Q8NI17 [Direct mapping]
Interleukin-31 receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0003713 [transcription coactivator activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019955 [cytokine binding]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042592 [homeostatic process]
GO:0043031 [negative regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 681 aa
77 kDa 		No 1
IL31RA-004
ENSP00000380048
ENST00000396836
Q8NI17 [Direct mapping]
Interleukin-31 receptor subunit alpha
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0003713 [transcription coactivator activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019955 [cytokine binding]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042592 [homeostatic process]
GO:0043031 [negative regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 582 aa
66.6 kDa 		No 0
IL31RA-005
ENSP00000427533
ENST00000490985
Q8NI17 [Direct mapping]
Interleukin-31 receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0003713 [transcription coactivator activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019955 [cytokine binding]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042592 [homeostatic process]
GO:0043031 [negative regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 622 aa
70.4 kDa 		No 1
IL31RA-201
ENSP00000297015
ENST00000297015
Q8NI17 [Direct mapping]
Interleukin-31 receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0003713 [transcription coactivator activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019955 [cytokine binding]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042592 [homeostatic process]
GO:0043031 [negative regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 745 aa
84.3 kDa 		Yes 1
IL31RA-202
ENSP00000347047
ENST00000354961
Q8NI17 [Direct mapping]
Interleukin-31 receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0003713 [transcription coactivator activity]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006952 [defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0019955 [cytokine binding]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042592 [homeostatic process]
GO:0043031 [negative regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 662 aa
74.9 kDa 		Yes 1
IL31RA-203
ENSP00000479432
ENST00000611895
A0A0C4DGU4 [Direct mapping]
Interleukin-31 receptor subunit alpha
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 324 aa
37.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.