Fields »
ABOUT
HELP
BLOG
TBX20

GENERAL INFORMATION

Gene name

 TBX20

Gene description

 T-box 20

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (heart muscle)
GTEx:Group enriched (heart muscle, urinary bladder)
FANTOM5:Group enriched (gallbladder, heart muscle, placenta, prostate, smooth muscle, urinary bladder, vagina)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, urinary bladder)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (gallbladder, heart muscle, placenta, prostate, smooth muscle, urinary bladder, vagina)

GENE INFORMATION

Gene name

 TBX20

Synonyms

Description

 T-box 20 (HGNC Symbol)

Entrez gene summary

 This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

 7

Cytoband

 p14.2

Chromosome location (bp)

 35202430 - 35254147

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164532 (version 83.38)

Entrez gene

 57057

UniProt

 Q9UMR3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UMR3

Antibodypedia

 TBX20 antibodies

PROTEIN BROWSER
TBX20-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBX20-001
ENSP00000386170
ENST00000408931
Q9UMR3 [Direct mapping]
T-box transcription factor TBX20
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001569 [patterning of blood vessels]
GO:0001706 [endoderm formation]
GO:0001764 [neuron migration]
GO:0001947 [heart looping]
GO:0003143 [embryonic heart tube morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003175 [tricuspid valve development]
GO:0003176 [aortic valve development]
GO:0003180 [aortic valve morphogenesis]
GO:0003193 [pulmonary valve formation]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003207 [cardiac chamber formation]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003272 [endocardial cushion formation]
GO:0003279 [cardiac septum development]
GO:0003344 [pericardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006936 [muscle contraction]
GO:0008015 [blood circulation]
GO:0008283 [cell proliferation]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010991 [negative regulation of SMAD protein complex assembly]
GO:0021524 [visceral motor neuron differentiation]
GO:0035050 [embryonic heart tube development]
GO:0035922 [foramen ovale closure]
GO:0036306 [embryonic heart tube elongation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048370 [lateral mesoderm formation]
GO:0055008 [cardiac muscle tissue morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060413 [atrial septum morphogenesis]
GO:0060577 [pulmonary vein morphogenesis]
Show all
 447 aa
49.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.