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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HCN1
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HCN1

Gene description

Hyperpolarization activated cyclic nucleotide gated potassium channel 1

Protein class

Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (WM-115)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most CNS tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

Supported based on 1 antibody.
HPA019195
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA019195

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A few cancers including cases of malignant melanomas, colorectal and breast cancers displayed weak cytoplasmic positivity. Malignant cells in general were negative.

GENE INFORMATION

Gene name

HCN1 (HGNC Symbol)

Synonyms

BCNG-1, BCNG1, HAC-2

Description

Hyperpolarization activated cyclic nucleotide gated potassium channel 1 (HGNC Symbol)

Entrez gene summary

The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]

Chromosome

5

Cytoband

p12

Chromosome location (bp)

45254950 - 45696498

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164588 (version 83.38)

Entrez gene

348980

UniProt

O60741 (UniProt - Evidence at protein level)

neXtProt

NX_O60741

Antibodypedia

HCN1 antibodies

PROTEIN BROWSER

HCN1-001
HCN1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HCN1-001
ENSP00000307342
ENST00000303230
O60741 [Direct mapping]
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Show all
Voltage-gated ion channels
   Cyclic Nucleotide-Regulated Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030552 [cAMP binding]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0042802 [identical protein binding]
GO:0045176 [apical protein localization]
GO:0046549 [retinal cone cell development]
GO:0055085 [transmembrane transport]
GO:0071320 [cellular response to cAMP]
GO:0071805 [potassium ion transmembrane transport]
Show all
890 aa
98.8 kDa
No 5
HCN1-002
ENSP00000489134
ENST00000634658
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0055085 [transmembrane transport]
Show all
295 aa
32.6 kDa
No 3

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