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COG5

GENERAL INFORMATION

Gene name

 COG5

Gene description

 Component of oligomeric golgi complex 5

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA020300
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable), liver cancer (unfavourable) and endometrial cancer (unfavourable).
Thyroid cancer p<0.001
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020300

GENE INFORMATION

Gene name

 COG5 (HGNC Symbol)

Synonyms

 GOLTC1, GTC90

Description

 Component of oligomeric golgi complex 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]

Chromosome

 7

Cytoband

 q22.3

Chromosome location (bp)

 107201555 - 107564514

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164597 (version 83.38)

Entrez gene

 10466

UniProt

 Q9UP83 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UP83

Antibodypedia

 COG5 antibodies

PROTEIN BROWSER
COG5-001
COG5-002
COG5-003
COG5-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COG5-001
ENSP00000334703
ENST00000347053
Q9UP83 [Direct mapping]
Conserved oligomeric Golgi complex subunit 5
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017119 [Golgi transport complex]
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 839 aa
92.7 kDa 		No 0
COG5-002
ENSP00000377228
ENST00000393603
Q9UP83 [Direct mapping]
Conserved oligomeric Golgi complex subunit 5
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017119 [Golgi transport complex]
Show all
 823 aa
90.8 kDa 		No 0
COG5-003
ENSP00000297135
ENST00000297135
Q9UP83 [Direct mapping]
Conserved oligomeric Golgi complex subunit 5
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017119 [Golgi transport complex]
Show all
 860 aa
94.9 kDa 		No 0
COG5-010
ENSP00000476238
ENST00000605888
U3KQU7 [Direct mapping]
Conserved oligomeric Golgi complex subunit 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0017119 [Golgi transport complex]
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 179 aa
19.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.