Expression of BMPER in cancer - Summary - The Human Protein Atlas

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BMPER

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BMPER
Gene description	BMP binding endothelial regulator
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (BJ, HBF TERT88, U-138 MG)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA018083
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018083

GENE INFORMATION
Gene name	BMPER (HGNC Symbol)
Synonyms	CRIM3, Cv2
Description	BMP binding endothelial regulator (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	33904911 - 34155872
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164619 (version 83.38)
Entrez gene	168667
UniProt	Q8N8U9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N8U9
Antibodypedia	BMPER antibodies

PROTEIN BROWSER

BMPER-001	BMPER-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BMPER-001 ENSP00000297161 ENST00000297161	Q8N8U9 [Direct mapping] BMP-binding endothelial regulator protein A0A090N7U6 [Target identity:100%; Query identity:100%] BMP-binding endothelial regulator protein Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Show all	GO:0001657 [ureteric bud development] GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0010594 [regulation of endothelial cell migration] GO:0030514 [negative regulation of BMP signaling pathway] GO:0042118 [endothelial cell activation] GO:0048839 [inner ear development] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	685 aa 76 kDa	Yes	0
BMPER-004 ENSP00000399843 ENST00000436222	C9JY72 [Direct mapping] BMP-binding endothelial regulator protein Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		161 aa 17.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.