Cell atlas - KCNK5 - The Human Protein Atlas

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KCNK5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KCNK5
Gene description	Potassium channel, two pore domain subfamily K, member 5
Protein class	Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Cell line enhanced (HEL, K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059148
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059148	CACO-2	No staining
	HPA059148	MCF7	Nucleus

GENE INFORMATION
Gene name	KCNK5 (HGNC Symbol)
Synonyms	K2p5.1, TASK-2
Description	Potassium channel, two pore domain subfamily K, member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	39188973 - 39229450
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164626 (version 83.38)
Entrez gene	8645
UniProt	O95279 (UniProt - Evidence at protein level)
neXtProt	NX_O95279
Antibodypedia	KCNK5 antibodies

PROTEIN BROWSER

KCNK5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK5-001 ENSP00000352527 ENST00000359534	O95279 [Direct mapping] Potassium channel subfamily K member 5 A0A024RD32 [Target identity:100%; Query identity:100%] Potassium channel, subfamily K, member 5, isoform CRA_a Show all	Transporters Transporter channels and pores Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005249 [voltage-gated potassium channel activity] GO:0005267 [potassium channel activity] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007588 [excretion] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071804 [cellular potassium ion transport] GO:0071805 [potassium ion transmembrane transport] Show all	499 aa 55.1 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.