Expression of KIF6 in cancer - Summary - The Human Protein Atlas

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KIF6

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KIF6
Gene description	Kinesin family member 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (RPMI-8226, SCLC-21H, SK-MEL-30)
HPA (normal tissue):	Group enriched (cerebral cortex, fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in testis, fallopian tube and CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Supported based on 1 antibody. HPA038811
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038811

GENE INFORMATION
Gene name	KIF6 (HGNC Symbol)
Synonyms	C6orf102, dJ1043E3.1, dJ137F1.4, dJ188D3.1, DKFZp451I2418, MGC33317
Description	Kinesin family member 6 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	39329990 - 39725405
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164627 (version 83.38)
Entrez gene	221458
UniProt	Q6ZMV9 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZMV9
Antibodypedia	KIF6 antibodies

PROTEIN BROWSER

KIF6-001	KIF6-002	KIF6-005	KIF6-006	KIF6-007	KIF6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIF6-001 ENSP00000287152 ENST00000287152	Q6ZMV9 [Direct mapping] Kinesin-like protein KIF6 Show all	Predicted intracellular proteins Show all	GO:0001673 [male germ cell nucleus] GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	814 aa 92.6 kDa	No	0
KIF6-002 ENSP00000404856 ENST00000441975	Q5JRK0 [Direct mapping] Kinesin-like protein Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	161 aa 17.8 kDa	No	0
KIF6-005 ENSP00000409417 ENST00000458470	H0Y718 [Direct mapping] Kinesin-like protein Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0005524 [ATP binding] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	689 aa 78.5 kDa	No	0
KIF6-006 ENSP00000377889 ENST00000394362	Q2MDE8 [Direct mapping] Kinesin-like protein KIF6 Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0005871 [kinesin complex] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	248 aa 28.3 kDa	No	0
KIF6-007 ENSP00000229913 ENST00000229913	Q6ZMV9 [Direct mapping] Kinesin-like protein KIF6 Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0007018 [microtubule-based movement] GO:0008017 [microtubule binding] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	265 aa 30.1 kDa	No	0
KIF6-201 ENSP00000441435 ENST00000538893	F6VGH2 [Direct mapping] Kinesin-like protein KIF6 Show all	Predicted intracellular proteins Show all	GO:0003777 [microtubule motor activity] GO:0005871 [kinesin complex] GO:0007018 [microtubule-based movement] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	293 aa 33.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.