Expression of SYTL3 in cancer - Summary

GENERAL INFORMATION
Gene name	SYTL3
Gene description	Synaptotagmin-like 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HMC-1, U-2 OS, U-266/70)
HPA (normal tissue):	Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several different tissue types, including thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA030584 , HPA030585 , HPA030586
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA030584	HPA030585	HPA030586

GENE INFORMATION
Gene name	SYTL3 (HGNC Symbol)
Synonyms	exophilin-6, SLP3
Description	Synaptotagmin-like 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of synaptotagmin-like proteins (SLPs). SLPs are peripheral membrane proteins that interact with RAB27A protein, and play a role in vesicular trafficking. Unlike, SLPs 1 and 2, this protein binds phospholipids in the presence of calcium ions. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Chromosome	6
Cytoband	q25.3
Chromosome location (bp)	158650014 - 158764876
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164674 (version 83.38)
Entrez gene	94120
UniProt	Q4VX76 (UniProt - Evidence at transcript level)
neXtProt	NX_Q4VX76
Antibodypedia	SYTL3 antibodies

PROTEIN BROWSER

SYTL3-001	SYTL3-201	SYTL3-202	SYTL3-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYTL3-001 ENSP00000297239 ENST00000297239	Q4VX76 [Direct mapping] Synaptotagmin-like protein 3 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016079 [synaptic vesicle exocytosis] GO:0017137 [Rab GTPase binding] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] GO:0070382 [exocytic vesicle] Show all	610 aa 68.6 kDa	No	0
SYTL3-201 ENSP00000353631 ENST00000360448	Q4VX76 [Direct mapping] Synaptotagmin-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016079 [synaptic vesicle exocytosis] GO:0017137 [Rab GTPase binding] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] GO:0070382 [exocytic vesicle] Show all	610 aa 68.6 kDa	No	0
SYTL3-202 ENSP00000356048 ENST00000367081	Q4VX76 [Direct mapping] Synaptotagmin-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016079 [synaptic vesicle exocytosis] GO:0017137 [Rab GTPase binding] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] GO:0070382 [exocytic vesicle] Show all	542 aa 60.9 kDa	No	0
SYTL3-203 ENSP00000483936 ENST00000611299	Q4VX76 [Direct mapping] Synaptotagmin-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0016079 [synaptic vesicle exocytosis] GO:0017137 [Rab GTPase binding] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019897 [extrinsic component of plasma membrane] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0042043 [neurexin family protein binding] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] GO:0070382 [exocytic vesicle] Show all	610 aa 68.6 kDa	No	0