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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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COL1A2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

COL1A2

Gene description

Collagen, type I, alpha 2

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Approved based on 1 antibody.
CAB032650
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
N/A
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

COL1A2 (HGNC Symbol)

Synonyms

OI4

Description

Collagen, type I, alpha 2 (HGNC Symbol)

Entrez gene summary

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]

Chromosome

7

Cytoband

q21.3

Chromosome location (bp)

94394561 - 94431232

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164692 (version 83.38)

Entrez gene

1278

UniProt

P08123 (UniProt - Evidence at protein level)

neXtProt

NX_P08123

Antibodypedia

COL1A2 antibodies

PROTEIN BROWSER

COL1A2-001
COL1A2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COL1A2-001
ENSP00000297268
ENST00000297268
P08123 [Direct mapping]
Collagen alpha-2(I) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001568 [blood vessel development]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005584 [collagen type I trimer]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006898 [receptor-mediated endocytosis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007266 [Rho protein signal transduction]
GO:0007596 [blood coagulation]
GO:0008217 [regulation of blood pressure]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0030674 [protein binding, bridging]
GO:0031012 [extracellular matrix]
GO:0042476 [odontogenesis]
GO:0042802 [identical protein binding]
GO:0043589 [skin morphogenesis]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048407 [platelet-derived growth factor binding]
GO:0050776 [regulation of immune response]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070208 [protein heterotrimerization]
GO:0071230 [cellular response to amino acid stimulus]
Show all
1366 aa
129.3 kDa
Yes 0
COL1A2-201
ENSP00000477719
ENST00000620463
A0A087WTA8 [Direct mapping]
Collagen alpha-2(I) chain
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
Show all
1364 aa
129.2 kDa
Yes 0

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