Expression of FNDC1 in cancer - Summary - The Human Protein Atlas

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FNDC1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FNDC1
Gene description	Fibronectin type III domain containing 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (gallbladder, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA030962 , HPA030963
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030962	HPA030963

GENE INFORMATION
Gene name	FNDC1 (HGNC Symbol)
Synonyms	bA243O10.1, dJ322A24.1, FNDC2, KIAA1866
Description	Fibronectin type III domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q25.3
Chromosome location (bp)	159169397 - 159272109
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164694 (version 83.38)
Entrez gene	84624
UniProt	Q4ZHG4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q4ZHG4
Antibodypedia	FNDC1 antibodies

PROTEIN BROWSER

FNDC1-001	FNDC1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FNDC1-001 ENSP00000297267 ENST00000297267	Q4ZHG4 [Direct mapping] Fibronectin type III domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005654 [nucleoplasm] Show all	1894 aa 205.6 kDa	Yes	0
FNDC1-002 ENSP00000333297 ENST00000329629	J3KNQ2 [Direct mapping] Fibronectin type III domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1790 aa 194.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.