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PGAM2

GENERAL INFORMATION

Gene name

 PGAM2

Gene description

 Phosphoglycerate mutase 2 (muscle)

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression most abundant in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA049237 , HPA060173
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA049237
HPA060173

GENE INFORMATION

Gene name

 PGAM2 (HGNC Symbol)

Synonyms

 PGAM-M

Description

 Phosphoglycerate mutase 2 (muscle) (HGNC Symbol)

Entrez gene summary

 Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 44062727 - 44065587

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164708 (version 83.38)

Entrez gene

 5224

UniProt

 P15259 (UniProt - Evidence at protein level)

neXtProt

 NX_P15259

Antibodypedia

 PGAM2 antibodies

PROTEIN BROWSER
PGAM2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGAM2-001
ENSP00000297283
ENST00000297283
P15259 [Direct mapping]
Phosphoglycerate mutase 2
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Enzymes
   ENZYME proteins
   Hydrolases
   Isomerase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004082 [bisphosphoglycerate mutase activity]
GO:0004083 [bisphosphoglycerate 2-phosphatase activity]
GO:0004619 [phosphoglycerate mutase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006941 [striated muscle contraction]
GO:0007219 [Notch signaling pathway]
GO:0007283 [spermatogenesis]
GO:0008152 [metabolic process]
GO:0010035 [response to inorganic substance]
GO:0016311 [dephosphorylation]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0043456 [regulation of pentose-phosphate shunt]
GO:0044281 [small molecule metabolic process]
GO:0046538 [2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity]
GO:0046689 [response to mercury ion]
GO:0048037 [cofactor binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
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 253 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.