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DLC1

GENERAL INFORMATION

Gene name

 DLC1

Gene description

 DLC1 Rho GTPase activating protein

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HBF TERT88, U-2197)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membrane and luminal expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA017753
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA017753

GENE INFORMATION

Gene name

 DLC1 (HGNC Symbol)

Synonyms

 ARHGAP7, DLC-1, HP, p122-RhoGAP, STARD12

Description

 DLC1 Rho GTPase activating protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

Chromosome

 8

Cytoband

 p22

Chromosome location (bp)

 13083361 - 13604610

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164741 (version 83.38)

Entrez gene

 10395

UniProt

 Q96QB1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96QB1

Antibodypedia

 DLC1 antibodies

PROTEIN BROWSER
DLC1-001
DLC1-002
DLC1-003
DLC1-004
DLC1-005
DLC1-008
DLC1-016
DLC1-019
DLC1-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLC1-001
ENSP00000276297
ENST00000276297
Q96QB1 [Direct mapping]
Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0003007 [heart morphogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0021575 [hindbrain morphogenesis]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0030900 [forebrain development]
GO:0032587 [ruffle membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
 1528 aa
170.6 kDa 		No 0
DLC1-002
ENSP00000351797
ENST00000358919
Q96QB1 [Direct mapping]
Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0003007 [heart morphogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0021575 [hindbrain morphogenesis]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0030900 [forebrain development]
GO:0032587 [ruffle membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
 1091 aa
122.8 kDa 		No 0
DLC1-003
ENSP00000321034
ENST00000316609
Q96QB1 [Direct mapping]
Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0003007 [heart morphogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0021575 [hindbrain morphogenesis]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0030900 [forebrain development]
GO:0032587 [ruffle membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
 498 aa
54.6 kDa 		No 0
DLC1-004
ENSP00000425878
ENST00000511869
Q96QB1 [Direct mapping]
Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0003007 [heart morphogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0021575 [hindbrain morphogenesis]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0030900 [forebrain development]
GO:0032587 [ruffle membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
 463 aa
50.9 kDa 		No 0
DLC1-005
ENSP00000422595
ENST00000512044
Q96QB1 [Direct mapping]
Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0003007 [heart morphogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0021575 [hindbrain morphogenesis]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0030900 [forebrain development]
GO:0032587 [ruffle membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
 1125 aa
126.7 kDa 		No 0
DLC1-008
ENSP00000428028
ENST00000520226
Q96QB1 [Direct mapping]
Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001843 [neural tube closure]
GO:0003007 [heart morphogenesis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0021575 [hindbrain morphogenesis]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0030900 [forebrain development]
GO:0032587 [ruffle membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042169 [SH2 domain binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:1900119 [positive regulation of execution phase of apoptosis]
Show all
 1017 aa
114.2 kDa 		No 0
DLC1-016
ENSP00000429537
ENST00000503161
E5RI70 [Direct mapping]
Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 49 aa
5.1 kDa 		No 0
DLC1-019
ENSP00000473289
ENST00000517868
R4GMP5 [Direct mapping]
Rho GTPase-activating protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 75 aa
8.4 kDa 		No 0
DLC1-020
ENSP00000488100
ENST00000631382
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 122 aa
13.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.