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A majority malignant tissues showed moderate nuclear positivity occasionally combined with cytoplasmic staining. A few cases of malignant melanomas, embryonal cancers of testis, lung, cervical and urothelial cancers displayed strong immunoreactivity. Prostate cancers, malignant gliomas and malignant lymphomas were in general weakly stained or negative while renal cancers were negative.
GENE INFORMATION
Gene name
ADCY1 (HGNC Symbol)
Synonyms
AC1
Description
Adenylate cyclase 1 (brain) (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]