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PEX2

GENERAL INFORMATION

Gene name

 PEX2

Gene description

 Peroxisomal biogenesis factor 2

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA011410 , HPA027729
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PEX2 (HGNC Symbol)

Synonyms

 PAF-1, PMP35, PXMP3, RNF72, ZWS3

Description

 Peroxisomal biogenesis factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q21.13

Chromosome location (bp)

 76980258 - 77001044

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164751 (version 83.38)

Entrez gene

 5828

UniProt

 P28328 (UniProt - Evidence at protein level)

neXtProt

 NX_P28328

Antibodypedia

 PEX2 antibodies

PROTEIN BROWSER
PEX2-001
PEX2-002
PEX2-003
PEX2-004
PEX2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PEX2-001
ENSP00000349543
ENST00000357039
P28328 [Direct mapping]
Peroxisome biogenesis factor 2
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0001764 [neuron migration]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005779 [integral component of peroxisomal membrane]
GO:0006635 [fatty acid beta-oxidation]
GO:0006699 [bile acid biosynthetic process]
GO:0007031 [peroxisome organization]
GO:0007399 [nervous system development]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016558 [protein import into peroxisome matrix]
GO:0016593 [Cdc73/Paf1 complex]
GO:0031648 [protein destabilization]
GO:0042632 [cholesterol homeostasis]
GO:0045540 [regulation of cholesterol biosynthetic process]
GO:0046872 [metal ion binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
Show all
 305 aa
34.8 kDa 		No 1
PEX2-002
ENSP00000428638
ENST00000522527
P28328 [Direct mapping]
Peroxisome biogenesis factor 2
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005778 [peroxisomal membrane]
GO:0005779 [integral component of peroxisomal membrane]
GO:0006635 [fatty acid beta-oxidation]
GO:0007031 [peroxisome organization]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016558 [protein import into peroxisome matrix]
GO:0016593 [Cdc73/Paf1 complex]
GO:0031648 [protein destabilization]
GO:0046872 [metal ion binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
Show all
 305 aa
34.8 kDa 		No 1
PEX2-003
ENSP00000428590
ENST00000520103
P28328 [Direct mapping]
Peroxisome biogenesis factor 2
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005778 [peroxisomal membrane]
GO:0005779 [integral component of peroxisomal membrane]
GO:0006635 [fatty acid beta-oxidation]
GO:0007031 [peroxisome organization]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016558 [protein import into peroxisome matrix]
GO:0016593 [Cdc73/Paf1 complex]
GO:0031648 [protein destabilization]
GO:0046872 [metal ion binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
Show all
 305 aa
34.8 kDa 		No 1
PEX2-004
ENSP00000429740
ENST00000519956
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 3 aa
0.3 kDa 		No 0
PEX2-006
ENSP00000429304
ENST00000518986
E5RIW9 [Direct mapping]
Peroxisome biogenesis factor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016021 [integral component of membrane]
Show all
 180 aa
20.8 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.