Tissue expression of PHKG1 - Summary - The Human Protein Atlas

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PHKG1

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PHKG1
Gene description	Phosphorylase kinase, gamma 1 (muscle)
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (skeletal muscle)
GTEx:	Tissue enriched (skeletal muscle)
FANTOM5:	Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in skeletal muscle.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA012057
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION
Gene name	PHKG1 (HGNC Symbol)
Synonyms	PHKG
Description	Phosphorylase kinase, gamma 1 (muscle) (HGNC Symbol)
Entrez gene summary	This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	7
Cytoband	p11.2
Chromosome location (bp)	56080283 - 56092996
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164776 (version 83.38)
Entrez gene	5260
UniProt	Q16816 (UniProt - Evidence at transcript level)
neXtProt	NX_Q16816
Antibodypedia	PHKG1 antibodies

PROTEIN BROWSER

PHKG1-001	PHKG1-003	PHKG1-009	PHKG1-201	PHKG1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHKG1-001 ENSP00000297373 ENST00000297373	Q16816 [Direct mapping] Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform A0A024RDL4 [Target identity:100%; Query identity:100%] HCG18830, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004689 [phosphorylase kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0006468 [protein phosphorylation] GO:0044281 [small molecule metabolic process] GO:0050321 [tau-protein kinase activity] Show all	387 aa 45 kDa	No	1
PHKG1-003 ENSP00000397193 ENST00000432123	C9J2Q6 [Direct mapping] Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	146 aa 16.9 kDa	No	0
PHKG1-009 ENSP00000389721 ENST00000446428	C9JME8 [Direct mapping] Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	117 aa 13.5 kDa	No	0
PHKG1-201 ENSP00000445440 ENST00000452681	Q16816 [Direct mapping] Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0004689 [phosphorylase kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005980 [glycogen catabolic process] GO:0006006 [glucose metabolic process] GO:0006468 [protein phosphorylation] GO:0019899 [enzyme binding] GO:0044281 [small molecule metabolic process] GO:0050321 [tau-protein kinase activity] Show all	419 aa 48.9 kDa	No	1
PHKG1-202 ENSP00000441528 ENST00000537360	F6VCX5 [Direct mapping] Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0004689 [phosphorylase kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005964 [phosphorylase kinase complex] GO:0005978 [glycogen biosynthetic process] GO:0006468 [protein phosphorylation] Show all	390 aa 45.5 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.