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EN2

GENERAL INFORMATION

Gene name

 EN2

Gene description

 Engrailed homeobox 2

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (melanoma)
HPA (cell line):Cell line enhanced (AF22, AN3-CA, HEK93)
HPA (normal tissue):Tissue enhanced (parathyroid gland, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results.

Reliability score

 Uncertain based on 1 antibody.
CAB025088
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB025088

GENE INFORMATION

Gene name

 EN2

Synonyms

Description

 Engrailed homeobox 2 (HGNC Symbol)

Entrez gene summary

 Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q36.3

Chromosome location (bp)

 155458129 - 155464831

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164778 (version 83.38)

Entrez gene

 2020

UniProt

 P19622 (UniProt - Evidence at transcript level)

neXtProt

 NX_P19622

Antibodypedia

 EN2 antibodies

PROTEIN BROWSER
EN2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EN2-001
ENSP00000297375
ENST00000297375
P19622 [Direct mapping]
Homeobox protein engrailed-2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0016020 [membrane]
GO:0030182 [neuron differentiation]
GO:0030901 [midbrain development]
GO:0030902 [hindbrain development]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048666 [neuron development]
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 333 aa
34.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.