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DEFA4

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GENERAL INFORMATION

Gene name

 DEFA4

Gene description

 Defensin, alpha 4, corticostatin

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (THP-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (THP-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DEFA4 (HGNC Symbol)

Synonyms

 DEF4, HP-4

Description

 Defensin, alpha 4, corticostatin (HGNC Symbol)

Entrez gene summary

 Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 6935822 - 6938338

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164821 (version 83.38)

Entrez gene

 1669

UniProt

 P12838 (UniProt - Evidence at protein level)

neXtProt

 NX_P12838

Antibodypedia

 DEFA4 antibodies

PROTEIN BROWSER
DEFA4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEFA4-001
ENSP00000297435
ENST00000297435
P12838 [Direct mapping]
Neutrophil defensin 4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0006952 [defense response]
GO:0019730 [antimicrobial humoral response]
GO:0019731 [antibacterial humoral response]
GO:0031640 [killing of cells of other organism]
GO:0042582 [azurophil granule]
GO:0045087 [innate immune response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050832 [defense response to fungus]
Show all
 97 aa
10.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.