Expression of DEFA6 in cancer - Summary - The Human Protein Atlas

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DEFA6

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DEFA6
Gene description	Defensin, alpha 6, Paneth cell-specific
Protein class	Plasma proteins Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Group enriched (BEWO, NB-4, RPMI-8226, SH-SY5Y, U-2197)
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression of paneth cells in intestinal tract

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA019462
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019462

GENE INFORMATION
Gene name	DEFA6 (HGNC Symbol)
Synonyms	DEF6, HD-6
Description	Defensin, alpha 6, Paneth cell-specific (HGNC Symbol)
Entrez gene summary	Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]
Chromosome	8
Cytoband	p23.1
Chromosome location (bp)	6924693 - 6926076
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164822 (version 83.38)
Entrez gene	1671
UniProt	Q01524 (UniProt - Evidence at protein level)
neXtProt	NX_Q01524
Antibodypedia	DEFA6 antibodies

PROTEIN BROWSER

DEFA6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEFA6-001 ENSP00000297436 ENST00000297436	Q01524 [Direct mapping] Defensin-6 Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0006952 [defense response] GO:0019731 [antibacterial humoral response] GO:0031640 [killing of cells of other organism] GO:0045087 [innate immune response] GO:0050832 [defense response to fungus] Show all	100 aa 11 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.