Expression of TMUB1 in cancer - Summary - The Human Protein Atlas

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TMUB1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMUB1
Gene description	Transmembrane and ubiquitin-like domain containing 1
Protein class	Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA029429
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029429

GENE INFORMATION
Gene name	TMUB1 (HGNC Symbol)
Synonyms	C7orf21, SB144
Description	Transmembrane and ubiquitin-like domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q36.1
Chromosome location (bp)	151081080 - 151083546
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164897 (version 83.38)
Entrez gene	83590
UniProt	Q9BVT8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BVT8
Antibodypedia	TMUB1 antibodies

PROTEIN BROWSER

TMUB1-001	TMUB1-002	TMUB1-003	TMUB1-004	TMUB1-005	TMUB1-006	TMUB1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMUB1-001 ENSP00000297533 ENST00000297533	Q9BVT8 [Direct mapping] Transmembrane and ubiquitin-like domain-containing protein 1 A0A090N8Q3 [Target identity:100%; Query identity:100%] Chromosome 7 open reading frame 21 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] Show all	246 aa 26.3 kDa	Yes	2
TMUB1-002 ENSP00000376565 ENST00000392818	Q9BVT8 [Direct mapping] Transmembrane and ubiquitin-like domain-containing protein 1 A0A090N8Q3 [Target identity:100%; Query identity:100%] Chromosome 7 open reading frame 21 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] Show all	246 aa 26.3 kDa	Yes	2
TMUB1-003 ENSP00000417519 ENST00000462940	Q9BVT8 [Direct mapping] Transmembrane and ubiquitin-like domain-containing protein 1 A0A090N8Q3 [Target identity:100%; Query identity:100%] Chromosome 7 open reading frame 21 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] Show all	246 aa 26.3 kDa	Yes	2
TMUB1-004 ENSP00000418709 ENST00000482202	Q9BVT8 [Direct mapping] Transmembrane and ubiquitin-like domain-containing protein 1 A0A090N8Q3 [Target identity:100%; Query identity:100%] Chromosome 7 open reading frame 21 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] Show all	246 aa 26.3 kDa	Yes	2
TMUB1-005 ENSP00000419214 ENST00000476627	Q9BVT8 [Direct mapping] Transmembrane and ubiquitin-like domain-containing protein 1 A0A090N8Q3 [Target identity:100%; Query identity:100%] Chromosome 7 open reading frame 21 Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] Show all	246 aa 26.3 kDa	Yes	2
TMUB1-006 ENSP00000420692 ENST00000488752	C9JCW7 [Direct mapping] Transmembrane and ubiquitin-like domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] Show all	171 aa 18.2 kDa	Yes	0
TMUB1-007 ENSP00000420516 ENST00000492838	C9JE12 [Direct mapping] Transmembrane and ubiquitin-like domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016021 [integral component of membrane] Show all	152 aa 16.1 kDa	Yes	0

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