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FZD6

GENERAL INFORMATION

Gene name

 FZD6

Gene description

 Frizzled class receptor 6

Protein class

 Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA017991
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA017991

GENE INFORMATION

Gene name

 FZD6 (HGNC Symbol)

Synonyms

 Hfz6

Description

 Frizzled class receptor 6 (HGNC Symbol)

Entrez gene summary

 This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

Chromosome

 8

Cytoband

 q22.3

Chromosome location (bp)

 103298433 - 103332866

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164930 (version 83.38)

Entrez gene

 8323

UniProt

 O60353 (UniProt - Evidence at protein level)

neXtProt

 NX_O60353

Antibodypedia

 FZD6 antibodies

PROTEIN BROWSER
FZD6-001
FZD6-002
FZD6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FZD6-001
ENSP00000429055
ENST00000522566
O60353 [Direct mapping]
Frizzled-6
A0A024R9E9 [Target identity:100%; Query identity:100%]
Frizzled homolog 6 (Drosophila), isoform CRA_a
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0017147 [Wnt-protein binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042813 [Wnt-activated receptor activity]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
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 706 aa
79.3 kDa 		Yes 7
FZD6-002
ENSP00000429528
ENST00000523739
O60353 [Direct mapping]
Frizzled-6
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0017147 [Wnt-protein binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042813 [Wnt-activated receptor activity]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
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 674 aa
75.6 kDa 		No 7
FZD6-201
ENSP00000351605
ENST00000358755
O60353 [Direct mapping]
Frizzled-6
A0A024R9E9 [Target identity:100%; Query identity:100%]
Frizzled homolog 6 (Drosophila), isoform CRA_a
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0001843 [neural tube closure]
GO:0001942 [hair follicle development]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0017147 [Wnt-protein binding]
GO:0030168 [platelet activation]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030901 [midbrain development]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033278 [cell proliferation in midbrain]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0035880 [embryonic nail plate morphogenesis]
GO:0042472 [inner ear morphogenesis]
GO:0042813 [Wnt-activated receptor activity]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045177 [apical part of cell]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
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 706 aa
79.3 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.