Cell atlas - INTS8 - The Human Protein Atlas

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INTS8

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	INTS8
Gene description	Integrator complex subunit 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA057299
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA057299	A-431	Nucleoplasm	Intensity
	HPA057299	CACO-2	Nucleoplasm
	HPA057299	U-2 OS	Nucleoplasm	Intensity

GENE INFORMATION
Gene name	INTS8 (HGNC Symbol)
Synonyms	C8orf52, FLJ20530, INT8, MGC131633
Description	Integrator complex subunit 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	8
Cytoband	q22.1
Chromosome location (bp)	94813311 - 94881746
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164941 (version 83.38)
Entrez gene	55656
UniProt	Q75QN2 (UniProt - Evidence at protein level)
neXtProt	NX_Q75QN2
Antibodypedia	INTS8 antibodies

PROTEIN BROWSER

INTS8-001	INTS8-006	INTS8-007	INTS8-008	INTS8-009	INTS8-010	INTS8-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INTS8-001 ENSP00000430338 ENST00000523731	Q75QN2 [Direct mapping] Integrator complex subunit 8 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	995 aa 113.1 kDa	No	0
INTS8-006 ENSP00000430180 ENST00000520526	H0YBS1 [Direct mapping] Integrator complex subunit 8 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		800 aa 91.1 kDa	No	0
INTS8-007 ENSP00000430033 ENST00000523808	E5RH10 [Direct mapping] Integrator complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		196 aa 22.1 kDa	No	0
INTS8-008 ENSP00000430049 ENST00000521860	H0YBQ1 [Direct mapping] Integrator complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		183 aa 20.1 kDa	No	0
INTS8-009 ENSP00000429056 ENST00000519053	E5RJL5 [Direct mapping] Integrator complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.5 kDa	No	0
INTS8-010 ENSP00000428260 ENST00000519457	E5RJF0 [Direct mapping] Integrator complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 16.6 kDa	No	0
INTS8-011 ENSP00000429340 ENST00000522171	E5RIN8 [Direct mapping] Integrator complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		204 aa 22.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.