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GEM

GENERAL INFORMATION

Gene name

 GEM

Gene description

 GTP binding protein overexpressed in skeletal muscle

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ hTERT+, U-266/70, U-87 MG)
HPA (normal tissue):Tissue enhanced (gallbladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA024798
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024798

GENE INFORMATION

Gene name

 GEM (HGNC Symbol)

Synonyms

 KIR

Description

 GTP binding protein overexpressed in skeletal muscle (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q22.1

Chromosome location (bp)

 94249253 - 94262350

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164949 (version 83.38)

Entrez gene

 2669

UniProt

 P55040 (UniProt - Evidence at protein level)

neXtProt

 NX_P55040

Antibodypedia

 GEM antibodies

PROTEIN BROWSER
GEM-001
GEM-002
GEM-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GEM-001
ENSP00000297596
ENST00000297596
P55040 [Direct mapping]
GTP-binding protein GEM
A0A024R9F5 [Target identity:100%; Query identity:100%]
GTP binding protein overexpressed in skeletal muscle, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006955 [immune response]
GO:0007067 [mitotic nuclear division]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0051233 [spindle midzone]
GO:0051276 [chromosome organization]
GO:0051310 [metaphase plate congression]
GO:0072686 [mitotic spindle]
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 296 aa
33.9 kDa 		No 0
GEM-002
ENSP00000379497
ENST00000396194
P55040 [Direct mapping]
GTP-binding protein GEM
A0A024R9F5 [Target identity:100%; Query identity:100%]
GTP binding protein overexpressed in skeletal muscle, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006955 [immune response]
GO:0007067 [mitotic nuclear division]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0051233 [spindle midzone]
GO:0051276 [chromosome organization]
GO:0051310 [metaphase plate congression]
GO:0072686 [mitotic spindle]
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 296 aa
33.9 kDa 		No 0
GEM-005
ENSP00000428258
ENST00000523433
E5RJF9 [Direct mapping]
GTP-binding protein GEM
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005525 [GTP binding]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
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 93 aa
10.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.