Expression of C9orf24 in cancer - Summary - The Human Protein Atlas

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C9orf24

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C9orf24
Gene description	Chromosome 9 open reading frame 24
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA053008
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053008

GENE INFORMATION
Gene name	C9orf24 (HGNC Symbol)
Synonyms	bA573M23.4, CBE1, MGC32921, MGC33614, NYD-SP22, SMRP1
Description	Chromosome 9 open reading frame 24 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear- or perinuclear-localized protein with no predicted domains or similarity to other known proteins. Expression of this gene is induced during the differentiation of bronchial epithelial cells, and the encoded protein may play a role in ciliogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	34379019 - 34397832
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164972 (version 83.38)
Entrez gene	84688
UniProt	Q8NCR6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NCR6
Antibodypedia	C9orf24 antibodies

PROTEIN BROWSER

C9orf24-001	C9orf24-002	C9orf24-003	C9orf24-004	C9orf24-005	C9orf24-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C9orf24-001 ENSP00000297623 ENST00000297623	Q8NCR6 [Direct mapping] Spermatid-specific manchette-related protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0002177 [manchette] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0043014 [alpha-tubulin binding] GO:0043623 [cellular protein complex assembly] GO:0048471 [perinuclear region of cytoplasm] Show all	262 aa 30.2 kDa	No	0
C9orf24-002 ENSP00000368421 ENST00000379126	Q8NCR6 [Direct mapping] Spermatid-specific manchette-related protein 1 Show all	Predicted intracellular proteins Show all	GO:0002177 [manchette] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0048471 [perinuclear region of cytoplasm] Show all	111 aa 13 kDa	No	0
C9orf24-003 ENSP00000368428 ENST00000379133	Q8NCR6 [Direct mapping] Spermatid-specific manchette-related protein 1 Show all	Predicted intracellular proteins Show all	GO:0002177 [manchette] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0048471 [perinuclear region of cytoplasm] Show all	127 aa 14.3 kDa	No	0
C9orf24-004 ENSP00000368422 ENST00000379127	Q8NCR6 [Direct mapping] Spermatid-specific manchette-related protein 1 Show all	Predicted intracellular proteins Show all	GO:0002177 [manchette] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0048471 [perinuclear region of cytoplasm] Show all	164 aa 19.1 kDa	No	0
C9orf24-005 ENSP00000389687 ENST00000444429	H0Y454 [Direct mapping] Spermatid-specific manchette-related protein 1 Show all	Predicted intracellular proteins Show all		126 aa 14.3 kDa	No	0
C9orf24-007 ENSP00000368419 ENST00000379124	Q8NCR6 [Direct mapping] Spermatid-specific manchette-related protein 1 Show all	Predicted intracellular proteins Show all	GO:0002177 [manchette] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0048471 [perinuclear region of cytoplasm] Show all	164 aa 19.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.